LABORATORY STUDIES OF INHALATION ANAESTHETICS
نویسندگان
چکیده
منابع مشابه
The Pharmacokinetics of Inhalation Anaesthetics: Clinical Applications.
The intensity and duration of drug effects, including those of anaesthetic agents, may be predicted if the site of action, potency, and methods of uptake, distribution and elimination of these substances in the body are understood. Reliable information on the first two points may be generally available and provided from animal experimentation or clinical study. The methods by which the patient ...
متن کاملThe effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats.
UNLABELLED Effects of common anaesthetics such as ether, methoxyflurane, isoflurane, carbon dioxide (at 100%, 80% or 60% admixed with O(2)) on toxicity and clinical pathology parameters in rats were investigated. Ether, methoxyflurane and 100% CO(2) induced toxicity in some animals. Erythrocyte, haemoglobin and haematocrit were reduced in females by 100% CO(2), methoxyflurane and isoflurane. Gl...
متن کاملCLINICAL PRACTICE Inhalation anaesthetics and climate change†
M. P. Sulbaek Andersen 1*, S. P. Sander 1, O. J. Nielsen 2, D. S. Wagner 3, T. J. Sanford Jr4 and T. J. Wallington 5 1 Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Mail Stop 183-901, Pasadena, CA 91109, USA 2 Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark 3 Department of Clinical Sciences, College of P...
متن کاملUptake and Elimination of Inhalation Anaesthetics during Outpatient Anaesthesia.
Outpatients expect to be able to walk into hospital and out again. They are usually unsedated and often apprehensive. When they are anaesthetized, induction must be rapid, depth of anaesthesia must be deep enough for the operative procedures performed—yet not so deep as to obtund protective reflexes—and prolonged recovery must be avoided. Many anaesthetic techniques are used with the aim of pro...
متن کاملTheoretical context-sensitive elimination times for inhalation anaesthetics.
BACKGROUND Context-sensitive times to 50%, 80%, and 90% elimination from the brain have been calculated for volatile anaesthetics. This does not represent complete recovery because there are important residual effects even at 90% elimination, and the effect of anaesthetic metabolism on the rate of elimination has not been considered. METHODS A physiologically based model of anaesthetic uptake...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1969
ISSN: 0007-0912
DOI: 10.1093/bja/41.10.827